MGMT Promoter Methylation and Parathyroid Carcinoma
نویسندگان
چکیده
منابع مشابه
MGMT promoter-enhancer single nucleotide polymorphism rs16906252 is associated with MGMT promoter methylation in cancer
The methylation of the O(6)-methylguanine DNA methyltransferase (MGMT) promoter is frequently observed in several cancer types. The potential correlation between the C>T allele at SNP rs16906252 and methylation in MGMT are being actively investigated and remain largely elusive. We studied the allelic pattern of MGMT methylation through meta-analysis. All eligible studies were identified by sear...
متن کاملMGMT promoter methylation and field defect in sporadic colorectal cancer.
BACKGROUND Sporadic colorectal cancers often arise from a region of cells characterized by a "field defect" that has not been well defined molecularly. DNA methylation has been proposed as a candidate mediator of this field defect. The DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is frequently methylated in colorectal cancer. We hypothesized that MGMT methylation could be one o...
متن کاملComprehensive Analysis of MGMT Promoter Methylation: Correlation with MGMT Expression and Clinical Response in GBM
O⁶-methylguanine DNA-methyltransferase (MGMT) promoter methylation has been identified as a potential prognostic marker for glioblastoma patients. The relationship between the exact site of promoter methylation and its effect on gene silencing, and the patient's subsequent response to therapy, is still being defined. The aim of this study was to comprehensively characterize cytosine-guanine (Cp...
متن کاملMGMT promoter methylation in Peruvian patients with glioblastoma
Purpose O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation predicts the outcome and response to alkylating chemotherapy in glioblastoma. The aim of this study is to evaluate the prevalence of MGMT methylation in Peruvian glioblastoma cases. Patients and methods We evaluated retrospectively 50 cases of resected glioblastoma during the period 2008-2013 at Instituto Nacional de E...
متن کاملAberrant Methylation of MGMT Promoter in HNSCC: A Meta-Analysis
BACKGROUND O6-methylguanine-DNA methyl-transferase (MGMT) gene, a DNA repair gene, plays a critical role in the repair of alkylated DNA adducts that form following exposure to genotoxic agents. MGMT is generally expressed in various tumors, and its function is frequently lost because of hypermethylation in the promoter. The promoter methylation of MGMT has been extensively investigated in head ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2019
ISSN: 2472-1972
DOI: 10.1210/js.2019-00175